The SASHG is involved in numerous activities to promote human genetics practice. The most important of these activities is the biennial SASHG congress. Each congress has had a number of invited international keynote speakers that has contributed towards our Society becoming known internationally. The biennial congress provides a forum for education and networking for all our members. Below is a list of the previous SASHG congresses.
| Year | Host | Venue | |
| 2023 | University of Cape Town, Joint with International Congress of Human Genetics | 19th | Cape Town |
| 2019 | Stellenbosch University | 18th | Cape Town |
| 2017 | Kwazulu Natal University | 17th | Durban |
| 2015 | University of Pretoria | 16th | Pretoria |
| 2013 | Wits University | 15th | Sandton |
| 2011 | University of Cape Town | 14th | Cape Town |
| 2009 | Stellenbosch University | 13th | Stellenbosch |
| 2007 | University of the Free State | 12th | Golden Gate |
| 2005 | University of Pretoria | 11th | Muldersdrift |
| 2003 | Kwazulu Natal University | 10th | Durban |
| 2001 | Limpopo University | 9th | Kruger Park |
| 1999 | University of Cape Town | 8th | Gordon’s Bay |
| 1997 | Wits University | 7th | Magaliesburg |
| 1995 | Stellenbosch University | 6th | West Coast |
| 1993 | University of the Free State | 5th | Bloemfontein |
| 1991 | University of Pretoria | 4th | Vereeniging |
| 1989 | Kwazulu Natal University | 3rd | Durban |
| 1988 | University of Cape Town | 2nd | Cape Town |
| 1987 | Wits University | 1st | Rustenburg |